I agree with Carter here:
"The last thing you want to do is make the
reader stop to figure out what you're on about."
UNLESS, of course, the punctuation is meant to make the reader stop and reconsider. Generally, standard punctuation guides the reader.
Reading aloud is another matter. The text you read from should be considered your SCRIPT, and you should mark it up whatever way helps you to deliver an excellent reading.
Bob
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